Authors : Rashid Ramazanzadeh, Fariba Farhadifar and Majid Mansouri
Abstract: The aim of this study was to determine the distribution and antibiotic susceptibility patterns of Extended-Spectrum Beta-Lactamase (ESBL) producing bacterial strains isolated from patients with community acquired infections at Sanandaj two major hospitals in Iran. The study took place at the Faculty of Medicine, Kurdistan University of Meical science, Sanandaj, Iran. About 158 g negative strains were evaluated isolated from various clinical specimens. The double-disk synergy test was performed on the isolates for the detection of ESBL. These genes were confirmed by PCR methods. The majority of community acquired ESBL types belong to CTX-M (10.76%) and SHV (10.76%). Resistance to ceftazidime and cefotaxime were 33.54 and 34.18%, respectively. Multiple resistances antibiotics were often associated with ESBL producing organisms. This is the first report of prevalence of ESBL producing isolates originating from the community in Sanandaj. ESBL producing isolates types especially CTX-M-producing gram negative bacteria are a rapidly developing problem in Iran. A heightened awareness of these organisms by clinicians and enhanced testing by laboratories including molecular surveillance studies is required to reduce treatment failures to limit their introduction into hospitals and to prevent the spread of these emerging pathogens within the community.
Rashid Ramazanzadeh, Fariba Farhadifar and Majid Mansouri, 2010. Etiology and Antibiotic Resistance Patterns of Community-Acquired Extended-Spectrum Beta-Lactamase-Producing Gram Negative Isolates in Sanandaj. Research Journal of Medical Sciences, 4: 243-247.