Authors : Marina Yu. Skorkina, Olga V. Cherkashina, Evgenia A. Sladkova, Tatiana A. Pogrebnyak, Ekaterina V. Zubareva, Oksana V. Vorobjeva, Elena A. Lipunova and Sergey V. Nadezhdin
Abstract: The participation of the elements of adenylate cyclases signaling pathways in the change of properties and cell architectonics of surface in the normal lymphocytes and tumor clone lymphocytes from patients with Chronic Lymphoid Leukemia (CLL) was proved. It has been shown under influence of adrenaline the stiffness increased as for normal lymphocyte by 36.4% (p<0.05) and so tumor lymphocyte by 233% (p<0.05) as compared with control. In the relief of surface abnormal lymphocytes was observed the decrease the number of globules protrusions and increase their height but in the normal lymphocytes was increased the number of globules protrusions with reduced height. Revealed features of cell’s surface properties may be used as objective criteria of functional conditions of lymphocytes during treatment of leukemia disease.
Marina Yu. Skorkina, Olga V. Cherkashina, Evgenia A. Sladkova, Tatiana A. Pogrebnyak, Ekaterina V. Zubareva, Oksana V. Vorobjeva, Elena A. Lipunova and Sergey V. Nadezhdin, 2015. Cell Architectonics and Surface Properties of Normal Lymphocytes and Lymphoblastic Cells from Patients with Chronic Lymphoid Leukemia in the Condition of Activation and Blockade of Elements Adenylate Cyclases Signaling Pathways. Research Journal of Medical Sciences, 9: 218-220.