Authors : Abdolhamid Zokaei, Nahid Aghdaei and Sara Joreir Ahmadi
Abstract: There are still questions regarding the effect of heparin on the accuracy of blood gas determination. The different dilutions of heparin may affect arterial blood gas analysis differently. The aim of the present study is to assess the effects of the different volumes of heparin added to blood sample of patients undergoing Coronary Artery Bypass Graft (CABG) surgery or valvular surgery. This randomized clinical trial was performed on 70 patients who were candidates for elective cardiac procedures including CABG surgery orvalvular surgery. From each patient three simultaneous blood samples were collected each with one of the three amounts of heparin (50, 200 and 500 units) by using a 1-cc blood sample with a 5-cc syringe. There was no significant differences in the three groups receiving the different amounts of heparin in terms of PH (p = 0.629), PaO2 (p = 0.711) and O2 saturation (p = 0.965) while the three indices of PaCO2 (p = 0.008), HCO3 (p = 0.001) and base excess (p = 0.001) all reduced by the increase in heparin volume in the syringes. Laboratory parameters such as serum sodium (Na) gradually increased (p = 0.004) by increasing in syringe the volume of heparin in the syringe while serum potassium (K), serum hemoglobin and serum hematocrit significantly decreased (p<0.05). Lactate level was independent to of the volume of heparin in the syringe (p = 0.231).
Abdolhamid Zokaei, Nahid Aghdaei and Sara Joreir Ahmadi, 2016. The Effect of Various Amount of Heparin on Analysis of Arterial Blood Gas in Adult Patients Undergoing Open Heart Surgery. Research Journal of Medical Sciences, 10: 191-193.