Authors : M.R. Sulaiman , Z.A. Zakaria , S. Moin , M.N. Somchit and Y.S. Chai
Abstract: The present study was carried out to establish the antinociceptive and anti-inflammatory activities of the aqueous extract of Lonicera japonica flowers� buds in various experimental animal models. The antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while, the anti-inflammatory was measured using the carrageenan-induced paw edema. The dried flower�s buds of L. japonica was added with distilled water (1:10 w v 1) and boiled for 2 h at 80�C. The supernatant collected was freeze-dried overnight and prior to use was diluted to the desired doses. The extract (30, 100 and 300 mg kg-1; administered intraperitoneally) exhibited significant (p<0.05) antinociceptive and anti-inflammatory activities in all assays used. In conclusion, the flower�s buds of L. japonica possessed potential antinociceptive and anti-inflammatory activities that require further in-depth studies.
M.R. Sulaiman , Z.A. Zakaria , S. Moin , M.N. Somchit and Y.S. Chai , 2008. Antinociceptive and Anti-Inflammatory Effects of Lonicera japonica Thunb. Research Journal of Pharmacology, 2: 38-42.