Authors : Kübra Kol, Cüneyt Toprak and Gökay Gün
Abstract: Eszopiclone is a type of medicine used in the treatment of insomnia with a hypnotic effect. The aim of this study is to create Eszopiclone 3 mg tablet formulation by providing homogeneous distribution of Eszopiclone raw material which is found in low amount in the drug, into the Excipients. In order to achieve homogeneous blending, 4 trial production and pilot studies were carried out using the geometric blending and elimination method. Trial 4 was optimized and the process validation study was approved. Acceptable content uniformity values of trial 4 and pilot study were calculated as 8.63 and 8.74%, respectively. In this study, the importance of geometric blending and elimination method is shown.
Kübra Kol, Cüneyt Toprak and Gökay Gün, 2020. Development of Low Dose Eszopiclone Drug Formulation by Using Geometric Blending Method. Research Journal of Pharmacology, 14: 44-48.