Authors : Setareh Soltany , Jafar A. Toussy and Mohamad Foruzesh Fard
Abstract: Symptomatic hemorrhoidal veins are one of the most common afflictions. Pain is the single most important reason why patients avoid hemorrhoidectomy. Spasm of internal sphincter plays an important role. Glyceryl Trinitrate (GTN) has been used widely as a chemical sphincterotomy agent. On the other hand, Nitiric oxide has some effects on wound healing. We designed this study to investigate topical GTN effects on postoperative pain and wound healing after hemorrhoidectomy. The study done in Semnan, Iran in years between 2006 and 2007. Patients with grades 3 and 4 hemorrhoids that undergone open hemorrhoidectomy entered the study. For the patients of case group 0.2% GTN ointment used. The post-operative pain and four weeks wound healing incidence assessed. Forty-four patients (22 for case and 22 for control groups) entered the study. Need for Opiates and NSAIDs thereafter (as indicators of pain) were lower in the case group. The four weeks wound healing incidence was higher and mean of time needed for it was lower in GTN group. Our study concluded that topical application of 0.2% GTN ointment can reduce postoperative pain and improve wound healing after open hemorrhoidectomy, but headache, which is a common side effect, can affect its usual use.
Setareh Soltany , Jafar A. Toussy and Mohamad Foruzesh Fard , 2009. The Effect of 0.2% Glyceryl Trinitrate Ointment on Pain and Wound Healing after Hemorrhoidectomy. Surgery Journal, 4: 8-12.