Authors : Mahmood Amini, Abdolali Pakdaman, Ghasem Mosaybei and Mohamad Rafeie
Abstract: The aim of this case control study was therefore to evaluate the correlation of preoperative serum High Mobility Group Box Protein-1 (HMGB1) levels in patients with various types of acute cholecystitis. This study was carried out from April, 2011 through May, 2012 and included 35 healthy control group and 68 patients (45 as mild and 23 as sever form) who presented at the Emergency Department of Valiasr Training and Research Hospital in Iran with acute abdominal pain who were clinically and sonographically diagnosed as acute cholecystitis. Clinical and demographical information as well as sonographic and operative findings were assessed in all patients. HMGB1, Liver Function Test (LFT), Complete Blood Count (CBC), amylase and lipase blood samples were determined on admission and 48-72 h after cholecystectomy. Patients with diagnosed acute cholecystitis were categorized into 2 groups of severity of infection based on operative and pathologic findings: mild cholecystitis (n = 45) and severe cholecystitis (n = 23). Although, the median level of HMGB1 was significantly higher in patients with acute cholecystitis compared to control group (p<0.007). There was not statistically significant difference in HMGB1 levels between patients with different types of acute cholecystitis. HMGB1 can be used as a diagnostic tool in acute cholecystitis but was not clear correlation with severity of acute cholecystitis.
Mahmood Amini, Abdolali Pakdaman, Ghasem Mosaybei and Mohamad Rafeie, 2012. The Evaluation of Correlation Between Serum High Mobility Group Box 1 (HMGB1) with Severity of Acute Cholecystitis. Surgery Journal, 7: 1-4.