Abstract: It is a truism that there is a remarkable gender difference in urban spatial interaction pattern. The tenor of this study is on the characterization of the variables that influence women`s propensity to interact spatially in Akure, Nigeria. Spatial interaction was assessed using the frequency of all-purpose trips made by women in Akure, Nigeria. The factors that influenced the frequency of spatial interaction were identified for female commuters in Akure and the nature of their influence was analyzed using the multiple regression model. The study makes recommendations on how to enhance women`s propensity to interact in the urban system in Akure. Ultimately, the study notes that economic empowerment is the elixir needed to address all the factors that either promoted or discouraged spatial interaction by women in Akure town and advocates a policy framework for women`s self-actualisation and capacity-building.