International Journal of Tropical Medicine

Year: 2012
Volume: 7
Issue: 3
Page No. 111 - 116

Effects of a Type V Phosphodiesterase Inhibitor (Tadalafil) on Indomethacin-Induced Gastric Ulceration in Rats

Authors : I. Ajiboye Kolawole and S. Oluwole Francis

References

Alphin, R.S. and J.W. Ward, 1967. Actions of hexopyrronium bromide on gastric secretion in dogs and on gastric secretion and ulceration in rats. Arch. Int. Pharmacodyn. Ther., 168: 82-100.
PubMed  |  

Duffin, R., C.A. Shaw and A.G. Rossi, 2008. Sildenafil reduces alcohol-induced gastric damage: Just say NO. Br. J. Pharmacol., 153: 623-624.
CrossRef  |  PubMed  |  Direct Link  |  

Elegbe, R.A., 1978. Comparative studies on starvation and indomethacin-induced ulcerations in albino rats. Biochem. Expt. Biol., 2: 159-166.
PubMed  |  Direct Link  |  

Elliott, S.N., W. McKnight, G. Cirino and J.L. Wallace, 1995. A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology, 109: 524-530.
PubMed  |  Direct Link  |  

Hirose, H., K. Takeuchi and S. Okabe, 1991. Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. Gastroenterology, 100: 1259-1265.
PubMed  |  Direct Link  |  

Karakaya, K., V. Hanci, S. Bektas, M. Can and H.B. Ucan et al., 2009. Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type 5 phosphodiesterase inhibitor. World J. Gastroenterol., 15: 5091-5096.

Khattab, M.M., M.Z. Gad and D. Abdallah, 2001. Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol. Res., 43: 463-467.
CrossRef  |  Direct Link  |  

Khoshakhlagh, P., M. Bahrololoumi-Shapourabadi, A. Mohammadirad, L. Ashtaral-Nakhai, B. Minaie and M. Abdollahi, 2007. Beneficial effect of phosphodiesterase-5 inhibitor in experimental inflammatory bowel disease: Molecular evidence for involvement of oxidative stress. Toxicol. Mech. Methods, 17: 281-288.
CrossRef  |  

Martin-Aragon, S., J. Benedi and A. Villar, 1994. Studies on the antiinflammatory and antiulcerogenic activities of Tuberaria lignose extracts in experimental animals. J. Pharmacol. Biol., 32: 27-32.
CrossRef  |  Direct Link  |  

Medeiros, J.V., G.G. Gadelha, S.J. Lima, J.A. Garcia and P.M. Soares et al., 2008. Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats. Br. J. Pharmacol., 53: 721-727.
CrossRef  |  PubMed  |  Direct Link  |  

Nakamura, C., M. Otaka, M. Odashima and S. Watanabe, 2003. Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates indomethacin-induced gastric mucosal injury in rats. Pathophysiology, 62: 449-454.
PubMed  |  Direct Link  |  

Santos, C.L., M.H. Souza, A.S. Gomes, H.P. Lemos, A.A. Santos, F.Q. Cunha and J.L. Wallace, 2005. Sildenafil prevents indomethacin-induced gastropathy in rats: Role of leukocyte adherence and gastric blood flow. Br. J. Pharmacol., 146: 481-486.
PubMed  |  Direct Link  |  

Saud, B., J. Nandi, G. Ong, S. Finocchiaro and R.A. Levine, 2005. Inhibition of TNF-α improves indomethacin-induced enteropathy in rats by modulating iNOS expression. Digestive Dis. Sci. 50: 1677-1683.
PubMed  |  Direct Link  |  

Sheehan, D.C. and B.B. Hrapchak, 1987. Theory and Practice of Histotechnology. 2nd Edn., Battelle Press, Columbus, OH., USA., ISBN: 9781574770674, Pages: 481.

Wallace, J.L. and P. del Soldato, 2003. The therapeutic potential of NO-NSAIDs. Fundam. Clin. Pharmacol., 17: 11-20.
CrossRef  |  PubMed  |  Direct Link  |  

Wallace, J.L., W. McKnight, B.K. Reuter and N. Vergnolle, 2000. NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology, 119: 706-714.
PubMed  |  Direct Link  |  

Whittle, B.J., 1977. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts and the actions of prostaglandins. Br. J. Pharmacol., 60: 455-460.
CrossRef  |  PubMed  |  Direct Link  |  

Design and power by Medwell Web Development Team. © Medwell Publishing 2024 All Rights Reserved