References

Aggarwal, B.B., A. Kumar and A.C. Bharti, 2003. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res., 23: 363-398.
Direct Link  |  

Anonymus, 2001. Wealth of India, supplement series. National Institute of Science Communication, Council of Scientific and Industrial Research, New Delhi, India.

Arbiser, J.L., N. Klauber, R. Rohan, V.R. Leeuwen and M.T. Huang et al., 1998. Curcumin is an in vivo inhibitor of angiogenesis. Mol. Med., 4: 376-383.

Balogun, E., M. Hoque, G.O.N.G. Pengfei, E. Killeen and C.J. Green et al., 2003. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J., 371: 887-895.
CrossRef  |  Direct Link  |  

Bundy, R., A.F. Walker, R.W. Middleton and J. Booth, 2004. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: A pilot study. J. Alter. Complement. Med., 10: 1015-1018.
PubMed  |  

Chattopadhyay, I., K. Biswas, U. Bandyopadhyay and R.K. Banerjee, 2004. Turmeric and curcumin: Biological actions and medicinal applications. Curr. Sci., 87: 44-53.
Direct Link  |  

Chen, A., J. Xu and A.C. Johnson, 2006. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of transcription factor Egr-1. Oncogene, 25: 278-287.

Cheng, A.L., C.H. Hsu, J.K. Lin, M.M. Hsu and Y.F. Ho et al., 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res., 21: 2895-2900.
PubMed  |  Direct Link  |  

Chiu, J., Z.A. Khan, H. Farhangkhoee and S. Chakrabarti, 2009. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-κB. Nutr., 25: 964-972.
Direct Link  |  

Deodhar, S.D., R. Sethi and R.C. Srimal, 1980. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J. Med. Res., 71: 632-634.
PubMed  |  Direct Link  |  

Epstein, J., I.R. Sanderson and T.T. MacDonald, 2010. Curcumin as a therapeutic agent: The evidence from in vitro, animal and human studies. Br. J. Nutr., 103: 1545-1557.
Direct Link  |  

Gaddipati, J.P., S.V. Sundar, J. Calemine, P. Seth and G.S. Sidhu et al., 2003. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage-resuscitation. Shock, 19: 150-156.
Direct Link  |  

Garcea, G., D.P. Berry, D.J. Jones, R. Singh and A.R. Dennison et al., 2005. Consumption of putative chemopreventive agent curcumin levels in the colorectum and pharmacodynamic consequences: Cancer Epidemiol. Biomarkers Prev., 14: 120-125.
PubMed  |  

Goel, A., A.B. Kunnumakkara and B.B. Aggarwal, 2008. Curcumin as "Curecumin": From kitchen to clinic. Biochem. Pharmacol., 75: 787-809.
CrossRef  |  PubMed  |  Direct Link  |  

Gupta, A.P., M.M. Gupta and S.J. Kumar, 1999. Simultaneous determination of curcuminoids in curcuma samples using high performance thin layer chromatography. J. Liq. Chromatogr. Relat. Technol., 22: 1561-1569.
CrossRef  |  Direct Link  |  

Hatcher, H., R. Planalp, J. Cho, F.M. Torti and S.V. Torti, 2008. Curcumin: From ancient medicine to current clinical trials. Cell. Mol. Life Sci., 65: 1631-1652.
CrossRef  |  Direct Link  |  

Hong, J., M. Bose, J. Ju, J.H. Ryu, X. Chen, S. Sang, M.J. Lee and C.S. Yang, 2004. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis, 25: 1671-1679.
PubMed  |  Direct Link  |  

Hu, M., Q. Du, I. Vancurova, X. Lin and E.J. Miller et al., 2005. Proapoptotic effect of curcumin on human neutrophils: Activation of the p38 mitogen-activated protein kinase pathway. Crit. Care Med., 33: 2571-2578.
Direct Link  |  

Huang, T.S., S.C. Lee and J.K. Lin, 1991. Suppression of c-Jun-AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc. National Acad. Sci., 88: 5292-5296.
PubMed  |  Direct Link  |  

Jagetia, G.C. and B.B. Aggarwal, 2007. Spicing up of the immune system by curcumin. J. Clin. Immunol., 27: 19-35.
CrossRef  |  PubMed  |  Direct Link  |  

Joe, B., M. Vijaykumar and B.R. Lokesh, 2004. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit. Rev. Food Sci. Nutr., 44: 97-111.
CrossRef  |  Direct Link  |  

Khanna, N.M., 1999. Turmeric: Nature's precious gift. Curr. Sci., 76: 1351-1356.
Direct Link  |  

Kumar, A., S. Dhawan, N.J. Hardegen and B.B. Aggarwal, 1998. Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-κB activation. Biochem. Pharmacol., 55: 775-783.
PubMed  |  Direct Link  |  

Lal, B., A.K. Kapoor, P.K. Agrawal, O.P. Asthana and R.C. Srimal, 2000. Role of curcumin in idiopathic inflammatory orbital pseudotumours. Phytother. Res., 14: 443-447.
CrossRef  |  PubMed  |  Direct Link  |  

Nadkarni, A.K., 1976. Indian Materia Medica. 1st Edn., Popular Prakashan, Mumbai, India.

Omoloso, A.D., 2001. Broad spectrum antibacterial activity of Allium cepa, Allium roseum, Trigonella foenum graecum and Curcuma domestica. Nat. Prod. Sci., 7: 13-16.
Direct Link  |  

Rajakrishnan, V., A. Jayadeep, O.S. Arun, P.R. Sudhakaran and V.P. Menon, 2000. Changes in the prostaglandin levels in alcohol toxicity: Effect of curcumin and N-acetylcysteine. J. Nutr. Biochem., 11: 509-514.
CrossRef  |  PubMed  |  Direct Link  |  

Ravindranath, V. and N. Chandrasekhara, 1981. In vitro studies on the intestinal absorption of curcumin in rats. Toxicol., 20: 251-257.
CrossRef  |  Direct Link  |  

Satoskar, R.R., S.J. Shah and S.G. Shenoy, 1986. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. J. Clin. Pharmacol. Ther. Toxicol., 24: 651-654.
Direct Link  |  

Scartezzini, P. and E. Speroni, 2000. Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol., 71: 23-43.
CrossRef  |  Direct Link  |  

Sharma, R.A., H.R. McLelland, K.A. Hill, C.R. Ireson and S.A. Euden et al., 2001. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin. Cancer Res., 7: 1894-1900.

Shoba, G., D Joy, T. Joseph, M. Majeed, R. Rajendran and P.S. Srinivas, 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med., 64: 353-356.
CrossRef  |  PubMed  |  Direct Link  |  

Siddiqui, A.M., X. Cui, R. Wu, W. Dong, M. Zhou and M. Hu et al., 2006. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit. Care Med., 34: 1874-1884.
Direct Link  |  

Srimal, R.C. and B.N. Dhawan, 1973. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J. Pharm. Pharmacol., 25: 447-452.
PubMed  |  

Taneja, R., J. Parodo, S.H. Jia, A. Kapus and O.D. Rotstein et al., 2004. Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit. Care Med., 32: 1460-1469.
Direct Link  |  

Toda, S., T. Miyase, H. Arichi, H. Tanizawa and Y. Takino, 1985. Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chem. Pharm. Bull., 33: 1725-1728.
PubMed  |  Direct Link  |