Abstract: The field experiment was conducted at Arba Minch University Agricultural Research Farm in Arba Minch district with the objective of determining response of maize varieties to combined application of nitrogen and phosphorus. The experiment was designed in randomized complete block consisting of ten treatments with three replications. The treatments consisted of five levels of combined NP₂O₅ viz., 0/0, 46/23, 46/46, 92/23 and 92/46 kg ha_–1 and two maize hybrid varieties, viz., V1 (BH-540) and V2 (BH-140). The results revealed that significant effect of NP₂O₅ rate and maize variety on all parameters. Maize variety BH-140 showed significant effect on number of grain rows per cob, number of grains per row, number of grains per cob, thousand grain weight and grain yield. The highest grain yield was recorded in response to application of 92:23 kg NP₂O₅ ha_–1 with maize variety BH-140. According to the result of this experiment hybrid maize variety BH-140 gave an optimum and profitable yield at the combined rate of 92:23 kg NP₂O₅ ha_–1.