Abstract: Sustainable development of regional competitive advantages are aimed to create a comfortable environment for living people and its consistent improvement, increasing effectiveness of business structures which are ultimately should leading to improve the life quality of the population in controlled territory. Amid the growing independence of the regions which are promoting greater competition between them the expansion and strengthening of inter-territorial economic ties, regional competitive advantages have become the determining factor in the economic development of our country and contributing reduction of regional asymmetries to promote more balanced development, catalyzing the national economy growth. The purpose of research is extending the methodological tools of development directions of formation and sustainable development of competitive advantages of the region. The study has been modified method of determining the integral factors of regional competitiveness by groups of indicators of social sphere and environmental situation and the possibility of justification of the block matching of existing coefficients data principle which are allowing us to refine and expand the methodological basis of development towards sustainable development of competitive advantages of the region. There various methods of economic research are used: comparative, the main arrayed data, fitted-graphic, economic-statistical technique and economic-mathematical (observation, summary, grouping, correlation and regression analysis).