Abstract: HIV-1 infection assumes the features of a systemic process affecting cellular cycling events and of inflammatory and neoplastic amplification. It would indeed appear that HIV-1 induces pathways of progression that are specifically transforming in terms of such amplification and self-amplification of cellular and microenvironmental events. The central nervous system in particular would constitute a manifestation of organ integrity that expresses the consequences of amplified transformation of pathobiologic lesions. Neoplasia of the lymphoreticular system would represent a characterization of the nature of such events as further projected by the HIV-1 infection evolving as AIDS dementia and Primary Lymphoma of the CNS and as Progressive Multifocal Leukoencephalopathy or opportunistic infection in general.