Abstract: Diseases of the guttural pouches are less commonly detected in horses, however, they cause significant risk to the health of the horse. Guttural pouch empyema is a disease of any age mostly associated with bacterial infection while guttural pouch tympany is a condition of young foals. The goal of this study is to document the occurrence of guttural pouch disorders among foals admitted to the Veterinary Teaching Hospital at King Faisal University, Al-Ahssa, Saudi Arabia. Three foals were referred between November 2005 and April 2006. The first foal was about 6 months old Arabian colt that had a history of intermittent bilateral nasal discharges. The foal was diagnosed with guttural pouch empyema based on physical and endoscopic examinations and treated with combined procaine penicillin and dehydrostreptomycin sulphate (Pen and Strep, Norbrook, Newry, North Ireland), for two weeks. Recovery was achieved and the foal came to full activity. The second two foals were five months old colt and one month old Arabian filly respectively that were admitted with a history of bilateral swelling at the parotid gland region. They were diagnosed with guttural pouch tympany based on physical and endoscopic examinations and radiographs. The first foal was recommended for surgery however it developed post surgery complications and died a month later. The second was operated and recovered fully after the surgery. These findings suggest that guttural pouch tympany and empyema must be considered in foals with signs of respiratory dysfunctions in this region of Saudi Arabia. Early diagnosis, aggressive and appropriate treatment are rewarding.