Authors : Manoj Kumar , A. Sanyal and D. Hemadri
Abstract: In this study, the response of Foot-and-Mouth Disease serotype Asia1 vaccine strain IND 491/97 to the immune pressure [antibodies raised in Bovine against IND 63/72 and in Guineapigs against IND 63/72 and IND 491/97] exerted in-vitro in BHK-21 cell culture system was analyzed in terms of genetic alterations at the nucleotide level. The Nr (neutralization resistant) viruses which were selected by growing in the presence of antibodies (Bovine Vaccinate Serum, BVS and Guineapig Serum, GPS) showed certain individual and also common changes in the structural protein coding P1 region. This shows that the virus responds to the antibodies raised in both bovine (natural host) and guineapig (experimental host). The result herein further extends the role of the host antibody in the rapid evolution of FMD Virus.
Manoj Kumar , A. Sanyal and D. Hemadri , 2006. In-vitro Immune Response of FMD Virus Serotype Asia1 Vaccine Strain (IND 491/97) to the Antibodies Raised in Bovine and Guineapigs. Journal of Animal and Veterinary Advances, 5: 538-541.