Abstract: The aim of this study was to evaluate the effect of chromium-methionin supplementation in high dosage on blood parameters and Insulin Resistance (IR) index in fructose induced insulin resistant rats. At first stage of the experiment, ten wistar rats were assigned as the healthy control group and sixteen rats were given Fructose (Fr) for 5 weeks in order to inducing insulin resistance. In the 2nd stage the insulin resistant rats were divided into Cr-fed group that additionally fed 1000 μg day-1 chromium as Chromium-L-Mmethionin (Cr-Met) and insulin resistant rats with no chromium supplementation for 6 weeks. In the first stage, IR was significantly induced (p<0.05) in rats receiving Fr. Plasma Fasting glucose, insulin, IR index and triglyceride contents were significantly (p<0.05) increased in Fr-fed group in comparison with the control. According to the results of second stage, IR index significantly (p<0.05) decreased after Cr-Met supplementation. The fasting insulin, glucose and triglycerides concentrations in Cr-Met treated group were lower (p<0.05) than the Fr-fed insulin resistant group. The results of this study indicated that chromium supplementation as Cr-Met could be effective for lowering IR index, fasting insulin, glucose and triglyceride in insulin resistant rats.
S.E. Ghiasi, R. Valizadeh, R. Rajabian, R. Jalal and B. Azimian, 2010. Effects of Dietary Chromium-Methionin Supplementation on Blood Metabolites and Insulin Resistance Index in Fructose-Fed Diabetic Rats. Journal of Animal and Veterinary Advances, 9: 2284-2289.