Abstract: TCAP is one of the titin interacting Z-disc proteins involved in the regulation and development of normal sarcomeric structure. In this study, researchers cloned the 5' upstream region of porcine TCAP gene. Bioinformatic analysis of the 5' regulatory region has revealed that in addition to several ubiquitous transcription factors binding sites (SP1, AP1 and C/EBP) were found, several putative muscle-specific transcription factor binding sites (MyoD, MyoG and MEF2) were present in this region. Tissue expression analysis showed that the porcine TCAP gene was expressed abundantly in skeletal muscle. The study suggested that TCAP gene might be a prospective candidate gene affecting muscle mass and meat quality traits in the pig and would lay the groundwork for the further investigations on the regulation and physiological function of porcine TCAP gene.
Mu Qiao, Huayu Wu, Jingshu Huang, Xianwen Peng, Guisheng Liu, Zheng Feng and Shuqi Mei, 2012. Promoter Characterization and Expression Pattern Analysis of Porcine TCAP Gene. Journal of Animal and Veterinary Advances, 11: 1876-1880.