Authors : Abolfathi Ali Akbar, Mohajeri Daryoush, Rezaie Ali and Nazeri Mehrdad
Abstract: Although, diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related to diabetes. This study was designed to evaluate the hepaoprotective properties of Green Tea Extract (GTE) in STZ-induced diabetes in rats. Wistar rats were made diabetic through single injection of STZ (75 mg kg-1 i.p.). The rats were randomly divided into four groups of 10 animals each: Group 1, healthy control; Group 2 non-diabetics treated with GTE administered orally (1.5%, w/v); Group 3, diabetics; Group 4, diabetics treated with GTE (1.5%, w/v) for 8 weeks. Serum biomarkers were assessed to determine hepatic injury. Malondialdehyde (MDA) and reduced Glutathione (GSH) contents were measured to assess free radical activity in the liver tissue. Hepatic antioxidant activities of glutathione peroxidase (GSH-Px), Superoxide Dismutase (SOD) and Catalase (CAT) were also determined. The biochemical findings were matched with histopathological verifications. Liver MDA content and serum levels of ALT, AST, ALP and bilirubin in Groups 3 significantly increased compared to Group 1 (p<0.05) and significantly decreased in Group 4 compared to Group 3 (p<0.05). Serum albumin level and GSH, SOD, CAT and GSH-Px contents of the liver in Group 3 were significantly decreased compared to Groups 1 (p<0.05) and were significantly increased in Group 4 compared to Group 3 (p<0.05). Histopathologically, the changes were in the same direction with biochemical findings. This study proved the hepatoprotective activity of GTE in experimentally induced diabetic rats.
Abolfathi Ali Akbar, Mohajeri Daryoush, Rezaie Ali and Nazeri Mehrdad, 2012. Green Tea Attenuates Hepatic Tissue Injury in STZ-Streptozotocin-Induced Diabetic Rats. Journal of Animal and Veterinary Advances, 11: 2081-2090.