Authors : Wessal M. Khamis, Bayader F. Abbas, Shaemaa Hadi Abdulsada, Mustafa Taha Mohammed, Alaa A. Sultan and Nedhal M. Khamis
Abstract: This research contain preparation of transitions metal complexes for metals (Mn+2, Co+2, Ni+2, Cu+2) with the mixed ligands of mefenamic acid and L-phenylalanine. The prepared complexes were investigated by using spectra methods of FTIR, UV-visible spectroscopy, molar conductivity, suspicibility magnetic measurements as well as melting points. Stereo chemistry of complexes were accomplished which showed that geometry of mixed ligand Mef:M:Phenyl alanine with (Mn+2, Ni+2, Cu+2) metal which have the molecular formula (513, 516.7, 521.5), respectively. Cobalt complex only has the distorted octahedral with molecular formula (588). Enzymatic activity study for prepared Ni+2, Cu+2 complexes were calculated the possibility of activation and reactivation (for previously inhibited enzymes) deactivation of enzymes AChE. MAO at human serum. These complexes showed ability for activation or reactivation of enzymes activity at human serum. Metal complexes of (Ni+2, Cu+2) were deactivated the enzymatic reaction. The order reaction of enzymatic reaction were achieved and it were first order reaction for (Ni+2,Cu+2) complexes as inhibitors for enzymatic reaction. Km and Vmax were calculated for the tow reactions.
Wessal M. Khamis, Bayader F. Abbas, Shaemaa Hadi Abdulsada, Mustafa Taha Mohammed, Alaa A. Sultan and Nedhal M. Khamis, 2019. Preparation, Investigation and Enzymatic Activity of Mixed Iigand Complexes of Mefenamic Acid and Phenyl Alanine with some Transition Metal. Journal of Engineering and Applied Sciences, 14: 734-743.