Abstract: This study examined the effectiveness of cognitive-behavioural therapy in managing stress among some trainee-teachers of a College of Education in Kwara State, Nigeria. The seventy-two participants employed for the study were randomly assigned into two experimental groups and a control group based on their high scores on an occupational stress scale. All the participants were administered the stress, depression, state and trait anxiety scales before and after treatment. The students in experimental group one received cognitive-behavioural therapy, those in experimental group two received relaxation training alone while the control group had none. Treatment lasted six weeks of twelve sessions. The post treatment scores of the students on stress, depression, state and trait anxiety were subjected to 3�2 ANCOVA and Scheffe Test using pretest scores as covariates. The results indicated that the two experimental groups had significant reductions in their levels of stress, depression, state and trait anxiety than the control group after treatment. The two experimental groups maintained their reductions from post treatment level to follow-up after twelve weeks but not the control group. The therapeutic implications of the findings for treating stress and other related problems were discussed.