Abstract: This study addresses biochemical and molecular changes associated with cytotoxicity induced by cyanide in the liver of Balb/C mice. In addition, the protective effect of aqueous extracts of Allium kurrat and Ricinus communis against Cyanide induce hepatotoxicity will be investigated. About 40 male Balb/C mice (35-40 g) were used in this study and divided into 4 groups (10 mice each); control group, received no treatment; cyanide group, administered with potassium cyanide (KCN) in drinking water at 4.5 mg kg b.w. daily for 30 days; cyanide and A. kurrat group, co-administered with 4.5 mg/kg b.w./day of KCN and 200 mg/kg b.w./day of A. kurrat aqueous extract for 30 days. Cyanide and Ricinus communis group, co-administered with 4.5 mg/kg b.w./day of KCN and 200 mg/kg b.w./day of R. communis aqueous extract for 30 days. Oxidative stress, antioxidant status and liver function markers were estimated in the liver. The expression levels of P53, Bcl-2, Interleukin 4 (IL-4) and Interleukin 12 (IL-12) genes were examined using quantitative real time PCR technique. When compared with the control group, livers of the cyanide group showed a significant decrease in enzymatic antioxidant activities such as Catalase (CAT), Superoxide Dismutase (SOD), Glutathione Reductase (GSH-Red), Glutathione Peroxidase (GSH-Px) and in the non-enzymatic antioxidant such as Glutathione (GSH) content. The level of liver Thiobarbituric Acid Reactive Substances (TBARS) showed a signifcant increase of Lipid Peroxidation (LPO) in the cyanide group compared with controls. The liver function markers such as Aspartic Transaminase (AST) and Alanine Transferase (ALT) and total bilirubin increased in the cyanide group compared to control group. A significant increase in serum total cholesterol, total lipids and total protein was observed in cyanide group in coparasion with controls. However, treating those animals exposed to cyanide by A. kurrat and R. communis extracts alleviated the changes in all measured parameters. P 53, Bcl-2, IL-4 and IL-12 genes showed over expression in response to cyanide toxicity showed over-expression in the liver of the cyanide group compared to control. However, the A. kurrat and R. communis extracts were able to manage the molecular changes induced by cyanide. It can be concluded that extracts of A. Kurrat and R. communis have promising role of for the treatment of cyanide induced hepatotoxicity.