Abstract: Foot reflexology is used in patients following cesarean delivery with the aim of adjusting vital signs and pain through inducing physical and psychologic relaxation. Therefore, this study was performed with the objective of assessing the effect of foot reflexology on physiologic indices and pain severity after cesarean study. The study had a quasi-experimental design. The study population consisted of all women who were hospitalized in the Obstetrics Department of Imam Reza Hospital, Kermanshah, Iran due to cesarean delivery. Of this, 20 were selected by convenient sampling and were randomly divided into two groups (10 in experimental group and 10 in control group). The required data were gathered and inserted into a checklist by interviewing and measuring vital signs. The data were analyzed by the Analysis of Variance (ANOVA) and post-hoc Tukey’s test. The results indicated that there was no significant difference between the two studied groups on day 1 (before starting the intervention) regarding pulse rate, systolic blood pressure, diastolic blood pressure, respiratory rate and temperature. But, on day 1 post-intervention and also when comparing the results on day 2 with the data on the first day, significant difference existed between the two groups. The results showed that foot reflexology can be a useful and effective Non-Pharmacological Method in decreasing pain and adjustment of physiologic indices (respiratory rate, temperature, pulse rate and blood pressure) amongst women after cesarean delivery.