Abstract: Pro-inflammatory cytokines have been noted to increase following exercise but their relationship to exercise-induced cardiac dysfunction has not previously been investigated. The aim of this study was to investigate the effects of 6 weeks of wrestling training in warm weather and cold on levels of troponin I and IL-1 β plasmain troponin I in teenager wrestlers. For this purpose, 24 wrestlers with an average weight of 64.81±6.25 kg, age 19.12±0.22 year and BMI of 21.72±0.56 kg. Square meter were randomly divided into 3 groups: warm weather, cold weather and control were divided. Blood samples from subjects in two phases, 48 h before the first session and 48 h after the last training session in the amount of 5 mL were taken from the brachial vein. The subjects in the wrestling specialized training was performed circular training during the 6 weeks in the two conditions of warm weather and cold. To analyze the data, t-test and ANOVA were used. Tukey’s test was used in significantly. The results showed that changes in levels of plasma troponin I was no significant difference between groups. Also after wrestlers trained in the cold weather levels of IL-1β plasma was a significant decrease, while the wrestlers trained in warm weather increased levels of IL-1β plasma but no significant increase. The results show that the probably increase in body temperature leads to an increase in the release of IL-1 β. It is possible that in flammatory cytokinesin predicting cardiovascular disease are more accurate and have an important role in the development of atherosclerosis.