Abstract: Infrastructure has become ubiquitous theme in a variety of areas of the policy debate. For instance, a number of studies have argued that generalized access to infrastructure services plays a key role in helping to reduce income inequality and enhancing productivity. Health care facility is one of these infrastructure. Paradoxically, the inadequate provision of infrastructure is more pronounced in the rural areas that habour greater proportion of the Nigerian population than the urban area. While frantic efforts are being made in providing for more infrastructure, it is therefore necessary to encourage adequate patronage of the available infrastructure particularly health facilities by the rural dwellers. This study reports the findings of a study that looked into the significant factors affecting the patronage of health care facilities by rural dwellers in Owo region, Nigeria. The study utilized a set of questionnaire designed to collect data on the health-seeking behaviour of 348 rural dwellers randomly selected from 22 rural settlements in the region. The study identified 20 health consumer variables that were fitted into regression model. Using a step-wise regression model, it concludes that only nine (9) of the 20 variables significantly affected the patronage of health care facilities by the rural dwellers in the region. Finally, the paper gives suggestions that would enhance these factors in the promotion of patronage of health care facilities in the region in particular and Nigeria in general which are adaptable to most developing countries of the World.