References

Adlard, P.A., V.M. Perreau, C. Engesser-Cesar and C.W. Cotman, 2004. The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci. Lett., 363: 43-48.
CrossRef  |  Direct Link  |  

Altmann, J., 1974. Observational study of behaviour: Sampling methods. Behaviour, 49: 227-267.
PubMed  |  

Beste, C., B.T. Baune, K. Domschke, M. Falkenstein and C. Konrad, 2010. Paradoxical association of the brain-derived-neurotrophic-factor val66met genotype with response inhibition. Neuroscience, 166: 178-184.
CrossRef  |  

Carlstead, D.K. and D. Shepherdson, 1994. Effects of environmental enrichment on reproduction. Zoo Biol., 13: 447-458.
CrossRef  |  

Chan, J.P., T.J. Unger, J. Byrnes and M. Rios, 2006. Examination of behavioral deficits triggered by targeting BDNF in fetal or postnatal brains of mice. Neuroscience, 142: 49-58.
CrossRef  |  

Chen, Z.Y., K. Bath, B. McEwen, B. Hempstead and F. Lee, 2008. Impact of genetic variant BDNF (Val66Met) on brain structure and function. Novartis. Found Symp., 289: 180-188.
PubMed  |  

Chourbaji, S., C. Brandwein, M.A. Vogt, C. Dormann, R. Hellweg and P. Gass, 2008. Nature vs. nurture: Can enrichment rescue the behavioural phenotype of BDNF heterozygous mice? Behav. Brain Res., 192: 254-258.
CrossRef  |  

Cotman, C.W. and N.C. Berchtold, 2002. Exercise: A behavioral intervention to enhance brain health and plasticity. Trends Neurosci., 25: 295-301.
CrossRef  |  PubMed  |  Direct Link  |  

Duan, W., J. Lee, Z. Guo and M.P. Mattson, 2001. Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. J. Mol. Neurosci., 16: 1-12.
CrossRef  |  

Duman, R.S., G.R. Heninger and E.J. Nestler, 1997. A molecular and cellular theory of depression. Arch. Gen. Psychiatry, 54: 597-606.
PubMed  |  

Gasic, G.P., J.W. Smoller, R.H. Perlis, M. Sun and S. Lee et al., 2009. BDNF, relative preference and reward circuitry responses to emotional communication. Am. J. Med. Genet. Part B: Neuropsychiatric Genet., 150B: 762-781.
CrossRef  |  

Gobbo, O.L. and S.M. O'Mara, 2005. Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor. Behav. Brain Res., 159: 21-26.
CrossRef  |  

Gong, P., A. Zheng, D. Chen, W. Ge and L.V. Changchao et al., 2009. Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy chinese han population. J. Mol. Neurosci., 38: 250-256.
CrossRef  |  

Govindarajan, A., B.S. Rao, D. Nair, M. Trinh, N. Mawjee, S. Tonegawa and S. Chattarji, 2006. Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proc. Nat. Acad. Sci. USA., 103: 13208-13213.
PubMed  |  

Gratacos. M., J.R. Gonzalez, J.M. Mercader, R. de Cid, M. Urretavizcaya and X. Estivill, 2007. Brain-derived neurotrophic factor val66met and psychiatric disorders: Meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders and schizophrenia. Biol. Psychiatry, 61: 911-922.
CrossRef  |  

Hashimoto, K., 2007. BDNF variant linked to anxiety-related behaviors. Bioessays, 29: 116-119.
PubMed  |  

Hemmings, S.M., C.J. Kinnear, L. van der Merwe, C. Lochner, V.A. Corfield, J.C. Moolman-Smook and D.J. Stein, 2008. Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsess-compulsive disorder (OCD). J. Biol. Psychiatry, 9: 126-134.
PubMed  |  

Hosey, G.R., 2000. Zoo animals and their human audiences: What is the visitor effect? Anim. Welfare, 9: 343-357.
Direct Link  |  

Humphries, R.E., R.H. Smith and R.M. Sibley, 1990. Effects of human disturbance on the welfare of park fallow deer. Applied Anim. Behav. Sci., 28: 302-302.
Direct Link  |  

Jiang, X., K. Xu, J. Hoberman, F. Tian and A.J. Marko et al., 2005. BDNF variation and mood disorders: A novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology, 30: 1353-1361.
PubMed  |  

Kang, J.I., K. Namkoong, R.Y. Ha, K. Jhung, Y.T. Kim and S.J. Kim, 2010. Influence of BDNF and COMT polymorphisms on emotional decision making. Neuropharmacology, 58: 1109-1113.
CrossRef  |  

Kernie, S.G., D.J. Liebl and L.F. Parada, 2000. BDNF regulates eating behavior and locomotor activity in mice. EMBO J., 19: 1290-1300.
CrossRef  |  

Lambert, T.J., S.M. Fernandez and K.M. Frick, 2005. Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice. Neurobiol. Learn. Mem., 83: 206-216.
Direct Link  |  

Lang, U.E., R. Hellweg, P. Kalus, M. Bajbouj and K.P. Lenzen et al., 2005. Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology, 180: 95-99.
CrossRef  |  

Lyons, W.E., L.A. Mamounas, G.A. Ricaurte, V. Coppola and S.W. Reid et al., 1999. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc. Nat. Acad. Sci. USA., 96: 15239-15244.
PubMed  |  

Mallapur, A., A. Sinha and N. Waran, 2005. Influences of visitor presence on the behaviour of captive lion-tailed macaques (Macaca silenus) housed in Indian zoos. Applied Anim. Behav. Sci., 94: 341-352.
CrossRef  |  

Monteleone, P., R. Zanardini, A. Tortorella, M. Gennarelli, E. Castaldo, B. Canestrelli and M. Maj, 2006. The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder. Neurosci. Lett., 406: 133-137.
CrossRef  |  

Neeper, S.A., F. Gomez-Pinilla, J. Choi and C.W. Cotman, 1996. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res., 726: 49-56.
CrossRef  |  

Nibuya, M., S. Morinobu and R.S. Duman, 1995. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci., 15: 7539-7547.
PubMed  |  

Ridder, S., S. Chourbaji, R. Hellweg, A. Urani and C. Zacher et al., 2005. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci., 25: 6243-6250.
PubMed  |  

Rybakowski, J.K., A. Borkowska, P.M. Czerski, M. Skibinska and J. Hauser, 2003. Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disorders, 5: 468-472.
PubMed  |  

Shen-Jin, L., P.A. Todd, Y. Yan, Y. Lin, F. Hongmei and W. Wan-Hong, 2010. The effects of visitor density on sika deer (Cervus nippon) behaviour in Zhu-Yu-Wan Park, China. Anim. Welfare, 19: 61-65.
Direct Link  |  

Webster, J.R. and L.R. Matthews, 2006. Behaviour of red deer following antler removal with two methods of analgesia. Livestock Sci., 100: 150-158.
Direct Link  |  

Whittington, C.J. and A.S. Chamove, 1995. Effects of visual cover on farmed red deer behaviour. Applied Anim. Behav. Sci., 45: 309-314.
Direct Link  |  

Yamada, K., M. Mizuno and T. Nabeshima, 2002. Role for brain-derived neurotrophic factor in learning and memory. Life Sci., 70: 735-744.
CrossRef  |  PubMed  |  Direct Link  |  

Yee, B.K., S.W. Zhu, A.H. Mohammed and J. Feldon, 2007. Levels of neurotrophic factors in the hippocampus and amygdala correlate with anxiety-and fear-related behaviour in C57BL6 mice. J. Neural Trans., 114: 431-444.
CrossRef  |  

Zhu, S.W., A. Codita, N. Bogdanovic, J. Hjerling-Leffler and P. Ernfors et al., 2009. Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice. Behav. Brain Res., 197: 339-346.
CrossRef  |