References

Abrams, G.D., 1977. Microbial effects on mucosal structure and function. Am. J. Clin. Nutr., 30: 1880-1886.
Direct Link  |  

Argenzio, R.A., J.A. Liacos, M.L. Levy, D.J. Meuten, J.G. Lecce and D.W. Powell, 1990. Villous atrophy, crypt hyperplasia, cellular infiltration and impaired glucose-Na absorption in enteric cryptosporidiosis of pigs. Gastroenterology, 98: 1129-1140.
PubMed  |  

Bardocz, S., G. Grant, D.S. Brown, A. Ralph and A. Pusztai, 1993. Polyamines in food-implications for growth and health. J. Nutr. Biochem., 4: 66-71.
CrossRef  |  Direct Link  |  

Bardocz, S., G. Grant, DS. Brown and A. Pusztai, 1998. Putrescine as a source of instant energy in the small intestine of the rat. Gut, 42: 24-28.
Direct Link  |  

Bardocz, S., T.J. Duguid, D.S. Brown, G. Grant, A. Pusztai, A. White and A. Ralph, 1995. The importance of dietary polyamines in cell regeneration and growth. Br. J. Nutr., 73: 819-828.
PubMed  |  

Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254.
CrossRef  |  PubMed  |  Direct Link  |  

Capano, G., K.J. Bloch, E.J. Schiffrin, J.A. Dascoli, E.J. Israel and P.R. Harmatz, 1994. Influence of the polyamine, spermidine, on intestinal maturation and dietary antigen uptake in the neonatal rat. J. Pediatr. Gastroenterol. Nutr., 19: 34-42.
PubMed  |  

Deignan, J.L., J.C. Livesay, L.M. Shantz, A.E. Pegg and W.E. O'Brien et al., 2007. Polyamine homeostasis in arginase knockout mice. Am. J. Physiol. Cell Physiol., 293: C1296-1301.
PubMed  |  

Deloyer, P., G. Dandrifosse, C. Bartholomeus, N. Romain and M. Klimek et al., 1996. Polyamine and intestinal properties in adult rats. Br. J. Nutr., 76: 627-637.
Direct Link  |  

Deng, D., K. Yao, W.Y. Chu, T.J. Li and R.L. Huang et al., 2009. Impaired translation initiation activation and reduced protein synthesis in weaned piglets fed a low-protein diet. J. Nutr. Biochem., 20: 544-552.
CrossRef  |  PubMed  |  

Doerfler, R.E., L.D. Cain, F.W. Edens, C.R. Parkhurst, M.A. Qureshi and G.B. Havenstein, 2000. D-xylose absorption as a measurement of malabsorption in poult enteritis and mortality syndrome. Poult. Sci., 79: 656-660.
Direct Link  |  

Dufour, C., G. Dandrifosse, P. Forget, F. Vermesse, N. Romain and P. Lepoint, 1988. Spermine and spermidine induce intestinal maturation in the rat. Gastroenterology, 95: 112-116.
PubMed  |  

Feuerstein, B.G., N. Pattabiraman and L.J. Marton, 1986. Spermine-DNA interactions: A theoretical study. Proc. Natl. Acad. Sci., 83: 5948-5952.
Direct Link  |  

Fioramonti, J., M.J. Fargeas, V. Bertrand, L. Pradayrol and L. Bueno, 1994. Induction of postprandial intestinal motility and release of cholecystokinin by polyamines in rats. Am. J. Physiol., 267: G960-965.
PubMed  |  

Greco, S., E. Niepceron, I. Hugueny, P. George, P. Louisot and M.C. Biol, 2001. Dietary spermidine and spermine participate in the maturation of galactosyltransferase activity and glycoprotein galactosylation in rat small intestine. J. Nutr., 131: 1890-1897.
PubMed  |  

Gyr, K., R.H. Wolf and O. Felsenfeld, 1974.. Intestinal absorption of D-xylose and folic acid in protein-deficient patas monkeys (Erythrocebus patas). Am. J. Clin. Nutr., 27: 350-354.
Direct Link  |  

Hampson, D.J., 1986. Alterations in piglet small intestinal structure at weaning. Res. Vet. Sci., 40: 32-40.
PubMed  |  

Jiang, Z.Y., L.H. Sun, Y.C. Lin, X.Y. Ma and C.T. Zheng et al., 2009. Effects of dietary glycyl-glutamine on growth performance, small intestinal integrity and immune responses of weaning piglets challenged with lipopolysaccharide. J. Anim. Sci., 87: 4050-4056.
Direct Link  |  

Jin, L., L.P. Reynolds, D.A. Redmer, J.S. Caton aand J.D. Crenshaw, 1994. Effects of dietary fiber on intestinal growth, cell proliferation and morphology in growing pigs. J. Anim. Sci., 72: 2270-2278.
Direct Link  |  

Johnson, L.R., 1988. Regulation of gastrointestinal mucosal growth. Physiol. Rev., 68: 456-502.

Johnson, L.R., P.D. Brockway, K. Madsen, J.A. Hardin and D.G. Gall, 1995. Polyamines alter intestinal glucose transport. Am. J. Physiol., 268: G416-423.
PubMed  |  

Kang, P., Y.L. Yin, Z. Ruan, J. Pan and Q. Hu et al., 2008. The effect of the replacement of lactose with partially hydrolyzed rice syrup on the small intestine development for weaned pigs from 7d to 21d. J. Sci. Food. Agric., 88: 1932-1938.

Kaouass, M., P. Deloyer and G. Dandrifosse, 1994. Intestinal development in suckling rat: Direct or indirect spermine action? Digestion, 55: 160-167.
PubMed  |  

Labarca, C. and K. Paigen, 1980. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem., 102: 344-352.
CrossRef  |  Direct Link  |  

Liu, Y.L., J.J. Huang, Y.Q. Hou, H.L. Zhu and S.J. Zhao et al., 2008. Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs. Br. J. Nutr., 100: 552-560.
PubMed  |  

Loser, C., A. Eisel, D. Harms and U.R. Folsch, 1999. Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development. Gut, 44: 12-16.
Direct Link  |  

Luna, L.G., 1968. Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 3rd Edn., McGraw-Hill, New York, Pages: 258.

Mansoori, B., H. Nodeh, M. Modirsanei, S. Rahbari and P. Aparnak, 2009. D-Xylose absorption test: A tool for the assessment of the effect of anticoccidials on the intestinal absorptive capacity of broilers during experimental coccidiosis. Anim. Feed. Sci. Technol., 148: 301-308.
CrossRef  |  Direct Link  |  

Motyl, T., T. Płoszaj, A. Wojtasik, W. Kukulska and M. Podgurniak, 1995. Polyamines in cow's and sow's milk. Comp. Biochem. Physiol. B: Biochem. Mol. Biol., 111: 427-433.
PubMed  |  

Pegg, A.E., 1986. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J., 234: 249-262.
PubMed  |  Direct Link  |  

Peulen, O., C. Pirlet, M. Klimek, G. Goffinet and G. Dandrifosse, 1998. Comparison between the natural postnatal maturation and the spermine-induced maturation of the rat intestine. Arch. Physiol. Biochem., 106: 46-55.
PubMed  |  

Sabater-Molina, M., E. Larque, F. Torrella, J. Plaza, T. Lozano, A. Munoz, S. Zamora, 2009. Effects of dietary polyamines at physiologic doses in early-weaned piglets. Nutrition, 25: 940-946.
PubMed  |  

Shirkey, T.W., R.H. Siggers, B.G. Goldade, J.K. Marshal, M.D. Drew, B. Laarveld and A.G. Van Kessel, 2006. Effects of commensal bacteria on intestinal morphology and expression of proinflammatory cytokines in the gnotobiotic pig. Exp. Biol. Med., 231: 1333-1345.
PubMed  |  

Sousadias, M.G. and T.K. Smith, 1995. Toxicity and growth-promoting potential of spermine when fed to chicks. J. Anim. Sci., 73: 2375-2381.
PubMed  |  

Sugita, Y., K. Takao, Y. Sugino, R. Kuwabara and A. Shirahata, 2011. Enhancement of gastrointestinal absorption of ovalbumin caused by spermine induces an increase in plasma histamine levels in mice sensitized to ovalbumin. Biol. Pharm. Bull., 34: 415-419.
Direct Link  |  

Tang, Z.R., Y.L. Yin, C.M. Nyachoti, R.L. Huang and T.J. Li et al., 2005. Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets. Domestic Anim. Endocrinol., 28: 430-441.
CrossRef  |  Direct Link  |  

Ter Steege, J.C., W.A. Buurman and P.P. Forget, 1997. Spermine induces maturation of the immature intestinal immune system in neonatal mice. J. Pediatr. Gastroenterol. Nutr., 25: 332-340.
PubMed  |  

Wild, G.E., A.S. Daly, N. Sauriol and G. Bennett, 1993. Effect of exogenously administered polyamine on the structural maturation and enzyme ontogeny of the postnatal rat intestine. Biol. Neonate., 63: 246-257.
PubMed  |  

Yin, Y.L., S.K. Baidoo, H. Schulze and P.H. Simmins, 2001. Effect of supplementing diets containing hulless barley varieties having different levels of non-starch polysaccharides with β-glucanase and xylanase on the physiological status of gastrointestinal tract and nutrient digestibility of weaned pigs. Livestock Prod. Sci., 71: 97-107.
CrossRef  |  

Zijlstra, R.T., K.Y. Whang, R.A. Easter and J. Odle, 1996. Effect of feeding a milk replacer to early-weaned pigs on growth, body composition and small intestinal morphology, compared with suckled littermates. J. Anim. Sci., 74: 2948-2959.
Direct Link  |