Authors : Mustafa Arslan, Berrin Isik, Mustafa Kavutcu and Omer Kurtipek
Abstract: Volatile agents are known to have an adverse effect on hepatic antioxidant defense mechanism as well as accelerating peroxidation. As a result, volatile agents are assumed to cause some structural changes in hepatic tissues. Halothane hepatotoxicity has been studied extensively but desflurane not clarified yet. In this research, we aim to determine the presence of oxidative stress and antioxidant activity in the liver tissue samples of the rats with anaesthetized desflurane. The study involved 40 female Wistar Albino rats. The rats were divided into two groups [(Group I, n = 20): Young female desflurane group (Group I-YFD, n = 10); Young female control group (Group I-YFC, n = 10), (Group II, n = 20): Old female desflurane group (Group II-OFD, n = 10); Old female control group (Group II-OFC, n = 10)]. The anaesthesia procedure was conducted with the groups of rats in a transparent plastic container. Desflurane was administered at 6% volume inspiratory concentration, 6 L min-1 in 100% O2 for 2 h. The control groups were not subjected to any procedures. Accordingly, Thiobarbutiric Acid-Reactive Substances (TBARS) level and Glutathione-S Transferase (GST), Superoxide Dismutase (SOD) and Nitric Oxide Synthase (NOS) enzyme activity were studied in the liver tissue samples of the rats to determine the presence of oxidative stress and antioxidant activity. Glutathione-S transferase, SOD, NOS enzyme activity and TBARS level after desflurane anesthesia was significantly higher in Group II-OFD than in Group I-YFD and Group II-OFC. Oxidative stress in the liver tissue samples of the old rats more than young rats after desflurane administration.
Mustafa Arslan, Berrin Isik, Mustafa Kavutcu and Omer Kurtipek, 2010. Effects of Desflurane on Oxidant/antioxidant Status of Female Young Versus Old Rat Liver Tissues. Journal of Animal and Veterinary Advances, 9: 2502-2507.