Authors : Eilyad Issabeagloo, Ali Rezaei, Kamran Mamaghani and Mehrdad Neshat Ghara Maleki
Abstract: Ketamine is a suitable injectable anesthetic in human and animal that has a low intestinal absorption rate. Its bioavailability in human with oral administration is 20±7% and with rectal administration in cat is 43.5±6.1%. This drug has some side effects such as hypertension, histamine releasing effects, hallucination, hyper salivation (especially with oral administration), etc. Clemastine is one ethanolaminic antihistamines with anticholinergic effects that can pass through blood-brain barrier and cause suppression of CNS. Then, it seems that co administration of clemastine and ketamine cause more effective and deep CNS depression effects. The aim of this study was evaluation of ketamine and clemastine CNS suppression effects in the manner of single and concomitant in cat. Ten free roaming male and mature cats received mentioned drugs (ketamine (20, 40 and 80 mg kg-1) and clemastine (0.68, 1.36 and 2.5 mg/cat)) as sublingual spray manner. Each animal was monitored continually by educated expert for CNS depression signs as graded on the behavioral scales. Clemastine alone in sublingual spray administration did not show a significant CNS depression effects. But ketamine in different doses showed a significant dose dependent effect. Concomitant use of clemastine with ketamine reduced CNS depression effects of ketamine. But duration of CNS depression was longer in co administration of these two drugs. Results showed that when ketamine sprayed in mouth (as sublingual form) a strong and long CNS depression was achieved.
Eilyad Issabeagloo, Ali Rezaei, Kamran Mamaghani and Mehrdad Neshat Ghara Maleki, 2012. Can Ethanolaminic H1 Blockers Improve CNS Suppression Effects of Ketamine as Oral Spray in Animal Model?. Journal of Animal and Veterinary Advances, 11: 3744-3748.