Abstract: To study the socio-demographic pattern and mode of presentation of organophosphorous intoxication, this study conducted at the department of internal Medicine in shohada ashayer hospital of khorramabad and Imam Khomeini hospital of sari, Iran. In this descriptive study, 286 cases of organophosphorous compound poisoning, admitted through the emergency department, were evaluated. In all the cases, a previously established clinical and therapeutic protocol was applied and the outcome was recorded. One-hundred sixty (54.54%) patients were male and 130 were (45.45%) female with the mean age of 25.04 years. Two hundred and twenty two (77.62%) cases were attempted suicides and 64 cases (22.37%) were due to accidental events. Mean age was 22.1 years in the 222 suicidal cases (77.62%) and 156 (70.27%) of them were less than 24 years. Among the suicide attempts, 126 (56.75%) were female patients. One-hundred fifty seven of cases were illiterate and 47.55% of the patients were in the lower middle socioeconomic status. The patients’ mean arrival time to the hospital after poisoning was 2.1�6.01 h. Exposure routes were gastrointestinal in 222 patients (77.62%), respiratory in 16 patients (5.59 %), dermal in 20 patients (6.99%) and both dermal and respiratory in 28 (9.79%). Death of 20 (6.99%) patients related to either the ingestion of higher doses or delay in approaching the hospital for emergency management. Causes of poisoning (suicide vs. non-suicide) and time interval between poisoning to arrival at hospital were major determinants of lethality. These findings call for a shift in emphasis in educating the masses towards first-aid care for intoxication.